Following the successfull 2020 Edition of Meet-EU, we are renewing the experience in 2021/2022, with the contribution of student teams from Heidelberg, Milano, Paris, Prag and Warsaw.
Similar to the 2020 edition, the topic of this years edition will be on the prediction of chromatin structure (topological associated domains and chromatin compartments) from Hi-C data. Data integration will play an important role, as additional datasets will be provided.
There are two sub-projects:
Possible questions could be how important TADs are for gene expression? Are they related to other chromosomal organisation structures? Can we define a classification of TADs? What are the epigenetic marks that can help in that task? How do the parameters influence the detection?
The classical resolution for detecting compartments is 100 kb. What if we increase that resolution? Can we extract more meaningful information? Can we detect the compartments based on inter-chromosomal contacts (instead of intra)? What are the biological implications? Can we define more than two compartments? What kind of epigenetic markers can help us determine a meaningful number and meaningful boundaries?
Students have the possibility to choose a shared course offered by one of the universities of the alliance. You can check the list of courses offered by each university on this website.